What is Tirzepatide?

What is Tirzepatide?

Tirzepatide (LY3298176) is a synthetic 39-amino-acid peptide based on the native GIP sequence, modified with a C20 fatty-diacid moiety, that acts as a dual agonist at the GIP and GLP-1 receptors.

What is it studied for in the laboratory?

Tirzepatide is used in the laboratory as a dual-agonist reference compound in receptor-binding and signalling assays, and in preclinical metabolic models designed to isolate the contribution of GIP-receptor activation on top of GLP-1-receptor activation.

Mechanism

Tirzepatide binds GIPR with affinity comparable to native GIP and GLP-1R with lower affinity than native GLP-1, producing a GIP-biased dual-agonist profile. At GLP-1R it shows biased signalling favouring cAMP generation over β-arrestin recruitment in reported assays.

Chemical identity

CAS

2023788-19-2

Molecular formula

C225H348N48O68

Class

Dual GIP / GLP-1 receptor agonist peptide

Form supplied

Solution, pre-filled multi-dose research pen

Primary literature

1. Coskun T, et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist… Mol Metab. 2018.
2. PubChem compound summary: Tirzepatide.

How is it supplied?

Tirzepatide is supplied by Body Pharm as a sealed, pre-filled multi-dose research pen with a batch-specific Certificate of Analysis (HPLC purity and identity). Supplied strictly for laboratory research. Not for human or veterinary use. No dosing information is provided.