Body Pharm Reta 32mg

Overview

Body Pharm Retatrutide 32 mg is supplied as a sealed, pre-filled multi-dose research pen containing 32 mg of retatrutide (LY3437943) in solution. Retatrutide is a synthetic 39-amino-acid peptide engineered as a single-molecule agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon receptors, with a C20 fatty-diacid side chain for albumin binding.

The pen is a laboratory research material. It is supplied strictly for laboratory research and is not for human or veterinary use. It is not a medicine, food, dietary supplement or cosmetic, and no medical, therapeutic or performance claims are made or implied. No dosing information is provided.

Research background

Retatrutide belongs to the incretin class of research peptides and is distinguished by its receptor coverage: it activates GIPR, GLP-1R and GCGR, three class B G-protein-coupled receptors. In the characterisation work published by Coskun and colleagues (2022), the molecule showed approximately balanced in-vitro potency at GIPR and GCGR with lower potency at GLP-1R relative to native GLP-1 [1].

In the laboratory, retatrutide is used as a tri-agonist reference ligand in receptor-pharmacology assays — cAMP accumulation, β-arrestin recruitment and receptor-internalisation assays in cell lines expressing each receptor individually — and in preclinical models of energy metabolism designed to isolate the contribution of glucagon-receptor signalling on top of dual GIP/GLP-1 activation [1][2]. Because the glucagon arm requires a GCGR-expressing model, retatrutide is not interchangeable with GLP-1-selective or dual-agonist comparators in comparative assays. See our receptor pharmacology comparison for how the three compounds differ.

Specification

• Compound: Retatrutide (LY3437943)
• Declared quantity: 32 mg per pen
• CAS: 2381089-83-2
• Molecular formula: C221H342N46O68
• Format: Solution, pre-filled multi-dose research pen
• Also available: Retatrutide 64 mg (waitlist)

Quality documentation

Every batch is HPLC-tested for purity and identity. The batch-specific Certificate of Analysis is linked above the specification table on this page and on our Certificates of Analysis page, and the batch number is printed on the pen label so the document can be matched to the unit received.

Storage and handling

Store refrigerated at 2–8 °C. Protect from light. Do not freeze. Handle only with appropriate personal protective equipment in a laboratory setting, and dispose of the pen as laboratory sharps waste in accordance with local regulations. Keep out of reach of children and animals.

Availability

Retatrutide 32 mg is currently on the waitlist. Registering your interest takes no payment; we notify you by email when the next batch is released.

Frequently Asked Questions

Is Retatrutide 32mg for human use?

No. Body Pharm Retatrutide 32 mg is supplied strictly for laboratory research. It is not for human or veterinary use, is not a medicine, and no dosing or administration information is provided.

What receptors does retatrutide act on?

Retatrutide is a tri-agonist at the GIP, GLP-1 and glucagon receptors. This three-receptor coverage is what distinguishes it from GLP-1-selective compounds such as semaglutide and dual GIP/GLP-1 agonists such as tirzepatide in laboratory receptor assays.

How is purity verified?

Each batch is tested by HPLC for purity and identity, and the Certificate of Analysis for that batch is published on this page and on the Certificates of Analysis page.

How should the pen be stored?

Refrigerated at 2–8 °C, protected from light, and never frozen.

When will the 32 mg pen be available?

Join the waitlist on this page and we will email you when the next batch is released. No payment is taken to join.

References

1. Coskun T, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist: from discovery to clinical proof of concept. Cell Metab. 2022. pubmed.ncbi.nlm.nih.gov/35772416
2. PubChem compound summary: Retatrutide. pubchem.ncbi.nlm.nih.gov/compound/Retatrutide