What is BPC-157 + TB-500?

What is BPC-157 + TB-500?

BPC-157 is a synthetic 15-amino-acid fragment (GEPPPGKPADDAGLV) of a protein sequence identified in human gastric juice. TB-500 is a synthetic peptide corresponding to the actin-binding region (LKKTETQ) of thymosin β4. The Body Pharm pen supplies the two as a combined blend.

What is it studied for in the laboratory?

BPC-157 is studied in preclinical models of angiogenesis, fibroblast migration and gastrointestinal cytoprotection. TB-500 and thymosin β4 are studied for actin sequestration, cell migration and modulation of inflammatory signalling. The pair is used together where a protocol needs both an angiogenic arm and an actin-regulation arm.

Mechanism

BPC-157 has been reported to modulate VEGFR2 expression and the nitric-oxide system in vitro and in preclinical models. Thymosin β4 sequesters G-actin via its LKKTET motif, regulating actin polymerisation and downstream cell-motility signalling.

Chemical identity

CAS (BPC-157)

137525-51-0

CAS (TB-500)

885340-08-9

Sequence (BPC-157)

Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

Sequence (TB-500)

Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (thymosin β4 17–23)

Form supplied

Solution, pre-filled multi-dose research pen (blend)

Primary literature

1. Sikiric P, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des. 2011.
2. Goldstein AL, et al. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005.

How is it supplied?

The BPC-157 + TB-500 blend is supplied by Body Pharm as a sealed, pre-filled multi-dose research pen with a batch-specific Certificate of Analysis (HPLC purity and identity). Supplied strictly for laboratory research. Not for human or veterinary use. No dosing information is provided.