What is MOTS-c?

What is MOTS-c?

MOTS-c is a 16-amino-acid peptide (MRWQEMGYIFYPRKLR) encoded by a short open reading frame within the mitochondrial 12S rRNA gene — one of the mitochondrial-derived peptides identified in the last decade.

What is it studied for in the laboratory?

MOTS-c is used in the laboratory to study mitochondrial-to-nuclear signalling, AMPK activation and folate–methionine cycle regulation in cell culture, and in preclinical models of metabolic homeostasis and cellular stress response.

Mechanism

In reported studies MOTS-c inhibits the folate cycle and de-novo purine synthesis, raising AICAR and activating AMPK; under metabolic stress it translocates to the nucleus and regulates adaptive gene expression through antioxidant-response elements.

Chemical identity

CAS

1627580-64-6

Molecular formula

C101H152N28O22S2

Sequence

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Form supplied

Solution, pre-filled multi-dose research pen (32 mg)

Primary literature

1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis… Cell Metab. 2015.
2. Kim KH, et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metab. 2018.

How is it supplied?

MOTS-c is supplied by Body Pharm as a sealed, pre-filled multi-dose research pen with a batch-specific Certificate of Analysis (HPLC purity and identity). Supplied strictly for laboratory research. Not for human or veterinary use. No dosing information is provided.