Body Pharm MOTS-C 32mg

Overview

Body Pharm MOTS-C 32 is a sealed, pre-filled multi-dose research pen containing 32 mg of MOTS-c in solution. MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide (MRWQEMGYIFYPRKLR) encoded by a short open reading frame within the mitochondrial 12S rRNA gene — one of the mitochondrial-derived peptides characterised over the last decade.

The pen is a laboratory research material. It is supplied strictly for laboratory research and is not for human or veterinary use. It is not a medicine, food, dietary supplement or cosmetic, and no medical, therapeutic or performance claims are made or implied. No dosing information is provided.

Research background

MOTS-c was described by Lee and colleagues (2015) as a mitochondrially encoded signalling peptide that inhibits the folate cycle and de-novo purine synthesis, raising AICAR and activating AMPK in cell culture and preclinical models [1]. Kim and colleagues (2018) subsequently showed that under metabolic stress MOTS-c translocates to the nucleus and regulates adaptive gene expression through antioxidant-response elements [2].

In the laboratory MOTS-c is used to study mitochondrial-to-nuclear signalling, AMPK activation, folate–methionine cycle regulation and cellular stress responses. It is frequently studied alongside NAD+ in models of mitochondrial function. See the MOTS-c monograph for identity data and primary literature.

Specification

• Compound: MOTS-c
• Declared quantity: 32 mg per pen
• CAS: 1627580-64-6
• Molecular formula: C101H152N28O22S2
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Format: Solution, pre-filled multi-dose research pen

Quality documentation

Every batch is HPLC-tested for purity and identity. The batch-specific Certificate of Analysis is published on this page and on our Certificates of Analysis page, and the batch number is printed on the pen label.

Storage and handling

Store refrigerated at 2–8 °C. Protect from light. Do not freeze. MOTS-c contains two methionine residues and is oxidation-sensitive; keep the pen sealed between uses. Handle only with appropriate personal protective equipment in a laboratory setting and dispose of the pen as laboratory sharps waste. Keep out of reach of children and animals.

Supply, dispatch and returns

Dispatched from the UK by tracked Royal Mail in plain outer packaging; most UK orders arrive within 1–3 working days. Shipping is free on UK pen orders. Unused, unopened pens with the seal intact may be returned within 14 days of delivery; opened pens cannot be returned. See shipping and returns.

Frequently Asked Questions

Is MOTS-c for human use?

No. Body Pharm MOTS-C 32 is supplied strictly for laboratory research and is not for human or veterinary use. No dosing or administration information is provided.

What is MOTS-c studied for in the laboratory?

Mitochondrial-to-nuclear signalling, AMPK activation, folate–methionine cycle regulation and cellular stress response in cell culture and preclinical models.

How is purity verified?

Each batch is HPLC-tested for purity and identity; the Certificate of Analysis for that batch is published on this page.

How should the pen be stored?

Refrigerated at 2–8 °C, protected from light, never frozen.

References

1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015. pubmed.ncbi.nlm.nih.gov/25738459
2. Kim KH, Son JM, Benayoun BA, Lee C. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metab. 2018. pubmed.ncbi.nlm.nih.gov/29983246