What is NAD+?

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a dinucleotide coenzyme found in every living cell, composed of two nucleotides joined through their phosphate groups — one bearing an adenine base, the other nicotinamide.

What is it studied for in the laboratory?

NAD+ is used in the laboratory as a substrate and cofactor in studies of redox metabolism, sirtuin (SIRT1–7) and PARP enzyme activity, mitochondrial respiration and the NAD+/NADH ratio in cell culture and preclinical ageing models.

Mechanism

NAD+ cycles between its oxidised (NAD+) and reduced (NADH) forms as the principal electron carrier of glycolysis, the TCA cycle and oxidative phosphorylation. It is also consumed as a substrate by sirtuins, PARPs and CD38, linking cellular energy state to chromatin regulation and DNA-repair signalling.

Chemical identity

CAS

53-84-9

Molecular formula

C21H27N7O14P2

Molecular weight

663.43 g/mol

Form supplied

Solution, pre-filled multi-dose research pen (1000 mg)

Primary literature

1. Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021.
2. PubChem compound summary: NAD+.

How is it supplied?

NAD+ is supplied by Body Pharm as a sealed, pre-filled multi-dose research pen with a batch-specific Certificate of Analysis (HPLC purity and identity). Supplied strictly for laboratory research. Not for human or veterinary use. No dosing information is provided.